Clonal Expansion of New Penicillin-Resistant Clade of Neisseria meningitidis Serogroup W Clonal Complex 11, Australia.

Shakeel Mowlaboccus,Keith A Jolley,James E Bray,Stanley Pang,Yung Thin Lee, Jane D Bew,David J Speers,Anthony D Keil,Geoffrey W Coombs,Charlene M Kahler

EMERGING INFECTIOUS DISEASES（2017）

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摘要

In Western Australia, Neisseria meningitidis serogroup W clonal complex 11 became the predominant cause of invasive meningococcal disease in 2016. We used core-genome analysis to show emergence of a penicillin-resistant clade that had the penA_ 253 allele. This new penicillin-resistant clade might affect treatment regimens for this disease.

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关键词

Australia,Neisseria meningitidis,Western Australia,antimicrobial resistance,bacteria,clonal complex 11,clonal expansion,core-genome analysis,meningitis/encephalitis,meningococcal disease,penicillin resistance,serogroup W

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