Lipopolysaccharide-induced suppression of periodontal ligament cell proliferation and apoptosis are strengthened under high glucose conditions.
Archives of Oral Biology(2017)
摘要
•Primary cultures of human PDL cells were prepared from extracted teeth of patients.•LPS-induced suppression of cell proliferation were strengthened by high glucose.•LPS-induced cell apoptosis were strengthened under high glucose condition.•LPS-induced decrease in Bcl-2/Bax ratio were strengthened by high glucose.•Glucose and LPS had a significant interaction for cell apoptosis.
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关键词
Lipopolysaccharide,High glucose,Cell apoptosis,BAX,BCL2
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