SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma
Clinical and Translational Radiation Oncology（2023）
Abstract
•A randomised phase II trial of radiotherapy dose escalation for pain control in MPM.•Comparison of 2 hypofractionated regimes (20 Gy/5# and 36 Gy/6#).•Highly conformal radiotherapy techniques used to aid safe dose escalation.•Primary outcome: pain control at week 5 at radiotherapy site.•Recruitment target: 112 patients from 10 to 15 UK centres.
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Key words
radiotherapy dose escalation,pain control
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