A new class of synthetic retinoid antibiotics effective against bacterial persisters

Wooseong Kim,Wenpeng Zhu,Gabriel Lambert Hendricks,Daria Van Tyne,Andrew D. Steele,Colleen E. Keohane,Nico Fricke,Annie L. Conery,Steven Shen,Wen Pan,Kiho Lee,Rajmohan Rajamuthiah,Beth Burgwyn Fuchs,Petia M. Vlahovska,William M. Wuest,Michael S. Gilmore,Huajian Gao,Frederick M. Ausubel,Eleftherios Mylonakis

NATURE（2018）

引用 279|浏览33

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摘要

Synthetic retinoid compounds can kill both growing and persister MRSA cells by disrupting the membrane lipid bilayer, and are effective in a mouse model of chronic MRSA infection.

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关键词

Antibiotics,High-throughput screening,Science,Humanities and Social Sciences,multidisciplinary

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