Hydrogen deuterium exchange reveals changes to protein dynamics of recombinant human erythropoietin upon N- and O- desialylation.
Journal of Pharmaceutical and Biomedical Analysis（2018）
Abstract
•Hydrogen deuterium exchange reveals changes in protein dynamics of human EPO upon desialylation that brings novel insights to the modulation of EPO conformation by sialylation.•First study to investigate the role of O-linked sialylation on protein dynamics for any proteins.•The approach can be generically applied to other therapeutics proteins.
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Key words
Hydrogen deuterium exchange,EPO,Sialylation,Conformational change,Glycoprotein therapeutics
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