Liberal versus Indicated Maternal Oxygen Supplementation in Labor: A Before-and-After Trial.

Background Although supplemental oxygen (SO (2) ) is routinely administered to laboring gravidas, benefits and harms are not well studied. Objective This article compares strategies of liberal versus indicated SO (2) therapy during labor on cesarean delivery (CD) rate and neonatal outcomes. Study Design A controlled, before-and-after trial of laboring women with term, singleton pregnancies. During an initial 8-week period, maternal SO (2) was administered at the discretion of the provider followed by an 8-week period where SO (2) was to be given only for protocol indications. Results Our study included 844 women. There was no difference in number of women receiving SO (2) (53% liberal vs. 50% indicated; p =0.33). For those receiving SO (2) , there was no difference in SO (2) duration (median, 89 minutes [interquartile range, 42-172] vs. 87 minutes [36-152]; p =0.42). There were no differences in overall CD rate (20% vs. 17%; p =0.70), CD for nonreassuring fetal status, or use of intrauterine resuscitative measures. There were more 5-minute APGAR<7 in the indicated group, but no difference in umbilical artery pH<7.1 or neonatal intensive care unit (NICU) admission. Conclusion Approximately half of women receive SO (2) intrapartum regardless of a strategy of liberal or indicated oxygen use. There were no clinically significant differences in outcomes between strategies.