Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats.
Neuroscience Letters(2017)
Abstract
•Fluoxetine facilitates hypoalgesia in thermal and inflammatory pain and induced mechanical hyperalgesia.•Fluoxetine aggravates stress-induced analgesia on thermal and inflammatory pain but not on mechanical pain.•5-HT system may be involved in changes of pain sensitivity after chronic stress exposure.
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Key words
Pain,Stress,Hyperalgesia,Hypoalgesia,Serotonin
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