Smallest Lectin-Like Peptide Identified from the Skin Secretion of an Endemic Frog, Hydrophylax Bahuvistara

Lectins are sugar-binding proteins and considered as attractive candidates for drug delivery and targeting. Here, we report the identifcation of the smallest lectin-like peptide (odorranalectin HYba) from the skin secretion of Hydrophylax bahuvistara which is being the shortest lectin-like peptide identifed so far from the frog skin secretion, with 15 amino acid residues. The peptide is the frst report from an Indian frog and lacks antimicrobial activity but strongly agglutinate intact human erythrocytes. The sequences at the L-fucose recognizing region is conserved as in other lectins reported from frog skin secretion and could be exploited for specifcity and drug targeting properties.