Diquats with Robust Chirality: Facile Resolution, Synthesis of Chiral Dyes and Application as Selectors in Chiral Analysis.
CHEMISTRY-A EUROPEAN JOURNAL(2018)
摘要
Diquats with extremely high racemization barriers with G(theor) of 233kJmol(-1) at 180 degrees C are described. Reported configurational robustness is due to a combination of two structural features: the rigid o-xylylene tether connecting the nitrogen atoms and the presence of two substituents in the bay region of the bipyridinium scaffold. The straightforward synthesis of diquats, plus facile resolution and derivatization make them attractive for chiral application studies. This is demonstrated by: 1)synthesis of the first non-racemic diquat dyes with pronounced chiroptical properties, and 2)capability of diquats to interact stereospecifically with chiral molecules. This suggests potential for diquat derivatives to be used as chiral selectors in separation methods.
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关键词
capillary electrophoresis,chiral selector,helical chirality,N-heterocyclic cations,racemization barrier
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