Novel prodrug PRX-P4-003, selectively activated by gut enzymes, may reduce the risk of iatrogenic addiction and abuse.
Drug and Alcohol Dependence（2018）
Abstract
•Unprecedented pancreatic-lipase based gut activation for abuse deterrence.•First report on PRX-P4-003 as a novel prodrug of a stimulant.•Selective oral but not intravenous drug activation.•Treatment implications for Alzheimer’s disease, Attention Deficit Hyperactivity Disorder (ADHD) and Binge-eating disorder.
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Key words
Addiction,Prodrug,Stimulant,Intravenous abuse,ADHD,Binge eating disorder
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