Primary cutaneous peripheral T-cell lymphoma not otherwise specified a rare and aggressive lymphoma.

Peripheral T-cell lymphomas not otherwise specified (PTCLs-NOS) have been defined as a kind of "Pandora's box", because of the broad morphologic spectrum, which features a prevalent nodal involvement and an aggressive, yet non-specific clinical course . PTCLs-NOS usually have a nodal presentation, while a skin spread occurs in approximately 20% of cases being regarded as a worse prognostic factor . PTCLs-NOS featuring skin lesions present at least six months before a hypothetical systemic involvement are regarded as a separate entity, named primary cutaneous PTCLs-NOS (PC-PTCLs-NOS) . This article is protected by copyright. All rights reserved.