In line monitoring of the powder flow behavior and drug content in a Fette 3090 feed frame at different operating conditions using Near Infrared spectroscopy.

•A NIR calibration model is developed to predict low drug content in a feed frame.•NIRs can be used to track when a process enters or leaves the mass steady state.•Variographic analysis demonstrated that the feed frame is an excellent sampling unit.•Differences in spectra baseline can affect the NIR calibration model predictions.•The die disc speed does not affect wave powder behavior inside of feed frame.