Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections.

Arthur R Celestin,Stephen R Odom,Konstantia Angelidou,Scott R Evans,Raul Coimbra,Christopher A Guidry,Joseph Cuschieri,Kaysie L Banton,Patrick J O'Neill,Reza Askari,Nicholas Namias,Therèse M Duane,Jeffrey A Claridge,E Patchen Dellinger,Robert A Sawyer,Charles H Cook

CLINICAL INFECTIOUS DISEASES（2017）

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摘要

Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.

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关键词

antibiotic resistance,desirability of outcome ranking,duration of antibiotic therapy,surgical infection,intra-abdominal infection

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