Bet-Inhibition By Jq1 Promotes Proliferation And Self-Renewal Capacity Of Hematopoietic Stem Cells

Mark Wroblewski, Marina Scheller-Wendorff,Raimund Bauer,Florian Udonta, Jara Schlichting,Lin Zhao,Isabel Ben Batalla,Victoria Gensch,Marek Wanior,Hanna Taipaleenmaki,Simona Bolamperti,Zeynab Najafova, Klaus Pantel, Carsten Bokemeyer,Eric Hesse,Stefan Knapp,Steven Johnsen,Sonja Loges

BLOOD（2017）

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摘要

Background/significance: Bromodomain and extra terminal domain (BET) proteins have been shown to be critical for maintaining the function of leukemia stem cells. Although BET-inhibitors are in clinical development and show promising activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET-inhibition on healthy hematopoietic (stem) cells is outstanding.

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