Effect of short- and medium-term toxicity of doxorubicin on spermatogenesis in adult Wistar rats

Robson Campos Silva,Daniella Maria Coelho Britto,Wagner de Fátima Pereira,Gustavo Eustáquio Alvin Brito-Melo,Cristiane Tolentino Machado,Marcelo Mattos Pedreira

Reproductive Biology（2018）

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摘要

•DRX reduced testis weight in rats due to apoptosis of germ cells.•DRX reduced the number of pachytene in stages I, II–III and VIII at seven and 14 days.•Testis presented loss of germ cell layers after 21 days.•Dimensions of seminiferous tubules reduced after DRX treatment.•Tubular compartment was reduced and intertubular improved after DRX treatment.

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关键词

Rat,Testis,Spermatogenesis,Stereology,Doxorubicin

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