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Atorvastatin dose-dependently promotes mouse lung repair after emphysema induced by elastase.

Adriana Correa Melo,Isabella Cattani-Cavalieri,Marina Valente Barroso,Nicolas Quesnot,Lycia Brito Gitirana,Manuella Lanzetti,Samuel Santos Valença

Biomedicine & Pharmacotherapy（2018）

Cited 16|Views22
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Abstract
•Elastase-induced pulmonary emphysema in mice is very similar to that in humans.•The pathophysiology involves proteolysis, inflammation and oxidative stress.•Treatment with atorvastatin in mice has been associated with lung protection.•Atorvastatin restored the lung parenchyma after emphysema.
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Key words
Emphysema,Elastase,Mouse,Atorvastatin,Lung repair
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