A surface magnetic imprinted polymers as artificial receptors for selective and efficient capturing of new neuronal nitric oxide synthase-post synaptic density protein-95 uncouplers.

Dandan Yao,Lei Zhang,Jiaojiao Huang,Chenghong Sun,Yu Zhang,Xiaoli Gu,Chong-Zhi Wang,Fei Li,Lina Chen,Chun-Su Yuan

Journal of Pharmaceutical and Biomedical Analysis（2018）

引用 6|浏览16

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摘要

•A surface magnetic molecularly imprinted polymers (SMMIPs) procedure was developed.•Good selection of SMMIPs was achieved using optimization experimental conditions.•SMMIPs were applied for specific isolation of potential nNOS–PSD-95 uncouplers from complex samples.•The isolated potential nNOS–PSD-95 uncouplers were verified using Neuroprotective effect and co-immunoprecipitation test in vitro.

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关键词

Neuronal nitric oxide synthase–post synaptic density protein-95 uncouplers,Magnetic molecularly imprinted polymers,Artificial receptors,Dispersive solid phase extraction,Stroke

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