In Silico Modeling of Bone Adaptation to Rest-Inserted Loading: Strain Energy Density Versus Fluid Flow as Stimulus.

•In silico model is used to study osteogenesis induced by rest-inserted loading.•Strain energy density (SED) and canalicular fluid flow are considered osteogenic.•SED may have limited success in explaining the in vivo new bone formation.•Fluid flow as stimulus has been able to fit experimental bone formation.•Incorporation of fluid flow will improve in silico models of bone adaptation.