Intrahippocampal injection of Cortistatin-14 impairs recognition memory consolidation in mice through activation of sst, ghrelin and GABA receptors.

•Central CST-14 resulted in impairment of long-/short-term recognition memory.•CST-14 do not impair long/short-term reconsolidation recognition memory.•These effects of CST-14 are involved in sst2, but not sst3 system.•The ghrelin system are involved in the memory-impairing actions of CST-14.•These actions of CST-14 are reversed by GABAA and GABAB receptor antagonisms.