The in vitro MIMIC® platform reflects age-associated changes in immunological responses after influenza vaccination.

Allison Dauner,Pankaj Agrawal, Jose Salvatico,Tenekua Tapia,Vipra Dhir,S Farzana Shaik,Donald R Drake,Anthony M Byers

Vaccine（2017）

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摘要

•MIMIC® system is a fully human in vitro model for testing vaccine immunogenicity.•In vitro MIMIC® recapitulates in vivo flu-specific immune responses in same cohort.•MIMIC® system shows reduced flu-specific B and T cell responses in elderly donors.•MIMIC® system reflects the role of donor-intrinsic factors on the immune response.

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关键词

MIMIC®,TIV,PBMC,APC,SA-HAI,ICCS,CDDC,MFI,HA

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