Genetic background impacts vaccine-induced reduction of pneumococcal colonization

Kirsten Kuipers,Saskia van Selm,Fred van Opzeeland,Jeroen D. Langereis,Lilly M. Verhagen,Dimitri A. Diavatopoulos,Marien I. de Jonge

Vaccine（2017）

引用 6|浏览43

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摘要

•Vaccine-induced reduction of S. pneumoniae colonization independent of genetic background.•Differences in magnitude of protection and in IgG and IL17A responses between the different mouse strains.•Protection against colonization is associated with similar immune responses in the different mouse strains.

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关键词

Streptococcus pneumoniae,Colonization,Intranasal vaccine,Vaccine-induced protection,Mouse genetic backgrounds,Distinct nasal cytokine profiles

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