Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013.

Christopher J Genito,Zoltan Beck,Timothy W Phares,Fanta Kalle,Keith J Limbach,Maureen E Stefaniak,Noelle B Patterson,Elke S Bergmann-Leitner,Norman C Waters,Gary R Matyas,Carl R Alving,Sheetij Dutta

Vaccine（2017）

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摘要

•FMP013 in ALFQ adjuvant induced a strong antibody and protective response in mice.•ALFQ was a more potent adjuvant than Montanide ISA 720.•ALFQ enhanced IgG2c, germinal center B-cells and antibody secreting cells.•ALFQ enhanced T-cell responses in a TH1 biased manner.•FMP013+ALFQ is under consideration for a human malaria vaccine trial.

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关键词

Adjuvant,Malaria,Vaccine,Liposomes,ALFQ,Monophosphoryl lipid A,QS-21,Plasmodium falciparum,Circumsporozoite protein,FMP013

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