Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression.
Journal of Dermatological Science(2018)
摘要
•An in vitro model for melanocyte senescence using UVB exposure is proposed.•The protocol relies on UVB exposure twice and subsequent 2-week cultivation.•Melanocyte senescence accompanies hyperpigmentation via prolonged p53 expression.
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关键词
UVR,UVsen,SAP,SA-β-Gal,TPA,CT,pTpT,HEMn,CDKN1A,PFTα,TYR,TYRP1,POMC,α-MSH,KITLG,HGF
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