TLR11 or TLR12 silencing reduces Leishmania major infection.

Cytokine(2018)

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摘要
•TLR11 and TLR12 expression is increased by virulent Leishmania major parasites.•TLR2-LPG interaction augments TLR11 and TLR12 expression.•IL-10 increases TLR11 and TLR12 expression.•TLR11 and TLR12 silencing reduces parasite growth.•The anti-leishmanial effect is accompanied by Th1 response.
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关键词
TLR11,TLR12,Anti-leishmanial,Macrophages,Cytokines
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