TLR11 or TLR12 silencing reduces Leishmania major infection.

Divanshu Shukla,Himanshu Singh Chandel,Sunit Srivastava,Prashant Chauhan,Surya Prakash Pandey,Ashok Patidar,Raja Banerjee,Debprasad Chattopadhyay,Bhaskar Saha

Cytokine（2018）

引用 14|浏览16

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摘要

•TLR11 and TLR12 expression is increased by virulent Leishmania major parasites.•TLR2-LPG interaction augments TLR11 and TLR12 expression.•IL-10 increases TLR11 and TLR12 expression.•TLR11 and TLR12 silencing reduces parasite growth.•The anti-leishmanial effect is accompanied by Th1 response.

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关键词

TLR11,TLR12,Anti-leishmanial,Macrophages,Cytokines

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