Deacetylation Of Mitofusin-2 By Sirtuin-1: A Critical Event In Cell Survival After Ischemia

MOLECULAR & CELLULAR ONCOLOGY（2016）

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摘要

Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

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关键词

Autophagy, ischemia/reperfusion, mitochondria, mitofusin 2, sirtuin 1

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