Isoform-dependent regulation of drebrin dynamics in dendritic spines.

•Drebrin A is more stable than drebrin E in dendritic spines.•Drebrin A-specific sequence is essential for the larger stability of drebrin.•Drebrin A likely binds to F-actin more preferentially than drebrin E in dendritic spines.•Drebrin isoform conversion seems to increase drebrin-bound stable F-actin.•The increase in drebrin stability may play a pivotal role in synapse formation.