High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.

Akihiro Takamiya,Jinichi Hirano, Yuki Ebuchi,Satoyuki Ogino, Kenichi Shimegi, Hiroyuki Emura, Kyoko Yonemori, Akiko Shimazawa,Gentaro Miura, Ayako Hyodo, Sari Hyodo, Tunetaka Nagai, Madoka Funaki,Masako Sugihara,Mitsuhiro Kita,Bun Yamagata,Masaru Mimura

NeuroImage: Clinical（2017）

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Abstract

•Antidepressant dose is negatively correlated with right temporoparietal NIRS signals during a verbal fluency task.•The effects of antidepressants are greater at higher dosage.•The effects of antidepressants should be considered when analyzing NIRS signals.

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Key words

Anatomical Therapeutic Chemical,defined daily dose,Diagnostic and Statistical Manual of Mental Disorders,Hamilton Rating Scale for Depression-17 item,International Classification of Diseases,magnetic resonance imaging,major depressive disorder,Montgomery Asberg Depression Rating Scale,near-infrared spectroscopy,oxy-hemoglobin,positron emission tomography,regional cerebral blood volume,verbal fluency task,World Health Organization

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