A simple route to a novel acid-sensitive 20( S )- O -linked camptothecin norcantharidin acid ester derivative.
ROYAL SOCIETY OPEN SCIENCE(2018)
摘要
A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.
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关键词
camptothecin,norcantharidin,synthesis,water solubility,tumour
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