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Topiramate modulates post-infarction inflammation primarily by targeting monocytes or macrophages.

Zhaohui Wang,Shiyuan Huang,Yuling Sheng,Xu Peng,Hui Liu,Nan Jin,Jun Cai,Yanwen Shu,Ting Li,Ping Li,Cheng Fan,Xiaofan Hu,Wenyong Zhang,Rui Long,Ya You, Caihong Huang,Yi Song,Chunhua Xiang,Jue Wang,Yong Yang,Kun Liu

Cardiovascular research（2017）

Cited 31|Views38
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Abstract
Control of the GABAA receptor activity in monocytes/macrophages can potently modulate post-infarction inflammation. Topiramate emerges as a promising drug, which may be feasible to translate for MI therapy in the future.
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Key words
GABAA receptor,Macrophage,Monocyte,Myocardial infarction,Topiramate
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