Modular assembly of the nucleolar pre-60S ribosomal subunit

Zahra Assur Sanghai,Linamarie Miller,Kelly R. Molloy,Jonas Barandun,Mirjam Hunziker,Malik Chaker-Margot,Junjie Wang,Brian T. Chait,Sebastian Klinge

NATURE（2018）

引用 143|浏览15

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摘要

Cryo-electron microscopy structures of multiple states along the assembly pathway of the nucleolar pre-60S ribosomal subunit suggest that folding of the pre-ribosomal RNA and sequential binding of transient assembly factors are regulated by steric hindrance among these factors.

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关键词

Cryoelectron microscopy,RNA,Science,Humanities and Social Sciences,multidisciplinary

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