Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents.

Til Bahadur Thapa Magar,Seung Hee Seo,Tara Man Kadayat,Hyunji Jo,Aarajana Shrestha,Ganesh Bist,Pramila Katila,Youngjoo Kwon,Eung-Seok Lee

Bioorganic & Medicinal Chemistry（2018）

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摘要

•A new series of hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines were synthesized.•Evaluated for topo I and IIα inhibitory activity, and antiproliferative activity.•Compounds showed selective topo IIα inhibitory activity.•SAR study indicated the importance of hydroxyphenyl-substitution at 4-position.

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关键词

Anticancer agents,5H-Chromeno[4,3-b]pyridines,Hydroxyl and chlorine-substitution,Selective topoisomerase IIα inhibition,SAR study

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