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Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes.

Lilian Julia Löwenau,Christian Zoschke,Robert Brodwolf,Pierre Volz,Christian Hausmann,Suvara Wattanapitayakul,Alexander Boreham,Ulrike Alexiev,Monika Schäfer-Korting

European Journal of Pharmaceutics and Biopharmaceutics（2017）

Cited 15|Views12
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Abstract
Extrinsic (photo) aging accelerates chronologically aging in the skin due to cumulative UV irradiation. Despite recent insights into the molecular mechanisms of fibroblast aging, age-related changes of the skin barrier function have been understudied. In contrast, the constantly increasing subpopulation of aged patients causes a clinical need for effective and safe (dermatological) treatment.
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Key words
Drug delivery systems,Reconstructed human epidermis,Senescence-associated secretory phenotype,Skin absorption,Skin aging,Tissue engineering
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