Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

Kerstin Reisinger,Veronika Blatz,Joep Brinkmann,Thomas R Downs,Anja Fischer,Frank Henkler,Sebastian Hoffmann,Cyrille Krul,Manfred Liebsch,Andreas Luch,Ralph Pirow,Astrid A Reus,Markus Schulz,Stefan Pfuhler

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2018）

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摘要

•The 3D Skin Comet assay is a new in vitro genotoxicity assay for the dermal exposure route.•Data of an ongoing validation exercise are presented.•A high predictivity was obtained, i.e. 100% in 4 laboratories, 70% in the fifth.•In parallel, a good intra- and inter- laboratory reproducibility was observed.•The assay is intended to follow up on positive findings from standard in vitro assays.

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关键词

In vitro genotoxicity,Comet assay,Skin,Phenion®FT,DNA damage,Dermal exposure

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