Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

Dariusz Zakrzewicz,Miroslava Didiasova,Marcus Krüger,Benedetto Daniele Giaimo,Tilman Borggrefe,Maren Mieth,Andreas C Hocke,Anna Zakrzewicz,Liliana Schaefer,Klaus T Preissner,Malgorzata Wygrecka

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2018）

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摘要

•LPS induces monomethylation of Eno-1 R50 (Eno-1R50me) and thus drives Eno-1 trafficking to the cell surface.•PRMT5 is a novel interacting partner of Eno-1 responsible for Eno-1R50me.•PRMT5 inhibition prevents Eno-1 exteriorization and diminishes the invasive potential of cancer cells.

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关键词

Cancer,Cell surface,Enolase,Invasion,PRMT5,Protein arginine methylation

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