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Solnatide Demonstrates Profound Therapeutic Activity in a Rat Model of Pulmonary Edema Induced by Acute Hypobaric Hypoxia and Exercise.

Qiquan Zhou,Dong Wang,Yunsheng Liu,Xiaohong Yang,Rudolf Lucas,Bernhard Fischer

Chest（2017）

Cited 25|Views6
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Abstract
Solnatide reduced pulmonary edema, increased occludin expression, and improved gas-blood barrier function during acute hypobaric hypoxia and exercise in rats. These results provide a rationale for the clinical application of solnatide to patients with pulmonary edema and exposure to a high-altitude hypoxic environment.
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Key words
cytokines,dexamethasone,HAPE rat model,high-altitude pulmonary edema,inflammation
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