An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP.

Sue Y Bae,James M Myslinski, Leslie R McMahon,Jude J Height,Andrew N Bigley,Frank M Raushel,Steven P Harvey

Enzyme and Microbial Technology（2018）

引用 18|浏览11

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摘要

•OPAA FL mutant has increased activity on several organophosphate nerve agents.•OPAA FL has GP activity comparable to soman activity.•Sarin enantiomers identified by stereospecific catalysis by two different enzymes.•Separation of sarin enantiomers by normal phase chiral LC column with APCI-MS.

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关键词

OPAA,Mutagenesis,Sarin,Soman,GP,LC-APCI-MS

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