Saroclides A And B, Cyclic Depsipeptides From The Mangrove-Derived Fungus Sarocladium Kiliense Hdn11-112
JOURNAL OF NATURAL PRODUCTS(2018)
摘要
Two new depsipeptides (1 and 2), together with three known related compounds, pestalotin (3), pestalotiopyrone L (4), and PC-2 (5), were discovered in the extract of a mangrove derived fungus Sarocladium kiliense HDN11-112. The structures of saroclides A and B were established by interpretation of extensive NMR spectroscopic data and X-ray crystallographic analysis. Compound 1 was also produced by Simplicillium lamellicola HDN13-430. Compounds 1 and 2 were inactive against five cancer cell lines and four pathogenic microorganisms, while compound 1 showed a lipid-lowering effect.
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关键词
cyclic depsipeptides,fungus,mangrove-derived
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