Multiparametric MR imaging of peripheral zone prostate cancer: effect of postbiopsy haemorrhage on cancer detection according to Gleason score and tumour volume.

Objective: To evaluate effect of postbiopsy hemorrhage on detection of peripheral zone (PZ) prostate cancer by multiparametric MR imaging according to Gleason score and tumor volume. Methods: This retrospective study included 54 biopsy-proven prostate cancer patients (median age, 67.0 years) who underwent multiparametric MR imaging. Two independent readers evaluated each sextant of the PZ using the PI-RADS v2. One reader recorded the presence or absence of hemorrhage per sextant on 7) weighted MR images. Areas under the receiver operating characteristic curves (AUCs) were used to evaluate cancer detection accuracy. Results: Postbiopsy hemorrhage was noted in 122 (37.7%) of 324 sextants of all patients. There was no significant difference in the AUC for detection of cancer with Gleason score >= 3 + 4 or volume >= 0.5 ml between sextants with and without hemorrhage (with hemorrhage, reader 1, 0.83 for Gleason score >= 3+ 4, 0.84 for tumor volume >= 0.5ml; reader 2, 0.74 for Gleason score >= 3+ 4, 0.77 for tumor volume >= 0.5ml: without hemorrhage, reader 1, 0.86 for Gleason score >= 3 + 4, 0.88 for tumor volume >= 0.5ml; reader 2, 0.79 for Gleason score >= 3 + 4, 0.83 for tumor volume >= 0.5 ml; p > 0.2 for all). Conclusion: Postbiopsy hemorrhage did not negatively affect the detection of clinically significant PZ prostate cancer on multiparametric MR imaging. Advances in knowledge: Under influence of postbiopsy hemorrhage, multiparametric MR can be useful for the detection of clinically significant PZ prostate cancer.