Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.
Bioorganic & Medicinal Chemistry Letters（2018）
摘要
A series of isoquinuclidines and bicyclic analogs were investigated as inhibitors of glycine uptake for the treatment of schizophrenia. Dimethylbenzamide 9 exhibited a dose-dependent response in a mouse MK801 locomotor assay as a model of the positive and negative symptoms of schizophrenia.
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关键词
GlyT1,Schizophrenia,NMDAr,N-Methyl-d-aspartate receptor,Glycine uptake inhibition
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