Suppression of HDAC2 in spinal cord alleviates mechanical hyperalgesia and restores KCC2 expression in a rat model of bone cancer pain.

Xinran Hou,Yingqi Weng,Tongxuan Wang,Bihan Ouyang,Yalin Li,Zongbin Song,Yundan Pan,Zhong Zhang,Wangyuan Zou,Changsheng Huang,Qulian Guo

Neuroscience（2018）

引用 23|浏览16

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摘要

•HDAC2 protein is up-regulated time dependently in the spinal cord of bone cancer pain rats.•Suppression of HDAC2 alleviates mechanical hyperalgesia of bone cancer pain rats.•Suppression of HDAC2 restores KCC2 expression in the spinal cord of bone cancer pain rats.

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关键词

BCP,DMSO,DRG,HDAC,HDACi,IOD,KCC2,MOR,PBS,PWMT,TSA,ZBG

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