Correction to: Decreased urinary excretion of the ectodomain form of megalin (A-megalin) in children with OCRL gene mutations

Chikushi Suruda,Shoji Tsuji,Sohsaku Yamanouchi,Takahisa Kimata,Nguyen Thanh Huan,Hiroyuki Kurosawa,Yoshiaki Hirayama,Hiroyasu Tsukaguchi,Akihiko Saito,Kazunari Kaneko

Pediatric nephrology (Berlin, Germany)（2022）

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Abstract

Decreased excretion of urinary A-megalin in four out of five patients with OCRL mutations suggests that LMW proteinuria may be caused by impaired megalin recycling within the proximal tubular cells. Homologous enzymes, similar to inositol polyphosphate-5-phosphatase B in mice, may help to compensate for defective OCRL-1 function during early childhood.

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Key words

Dent disease,Inositol polyphosphate-5-phosphatase,Lowe syndrome,Megalin,OCRL,Tubular proteinuria

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