Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

Robert Hänsel-Hertsch,Jochen Spiegel,Giovanni Marsico,David Tannahill,Shankar Balasubramanian

NATURE PROTOCOLS（2018）

引用 171|浏览13

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摘要

This protocol adapts traditional ChIP-seq for the detection of DNA secondary structures through the use of a G4-structure-specific single-chain antibody. This enables the determination of G4 structure formation genome-wide in chromatin.

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关键词

Chromatin immunoprecipitation,Chromatin structure,Epigenetics,Epigenomics,Next-generation sequencing,Life Sciences,general,Biological Techniques,Analytical Chemistry,Microarrays,Computational Biology/Bioinformatics,Organic Chemistry

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