A Murine Model of Myocardial Ischemia-Reperfusion Injury.
TRAUMATIC AND ISCHEMIC INJURY: METHODS AND PROTOCOLS(2018)
摘要
Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.
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关键词
LAD ligation,Left anterior descending coronary artery,Myocardial infarction,Myocardial ischemia–reperfusion,Permanent ligation
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