CRISPRs from scratch
NATURE MICROBIOLOGY（2018）
摘要
CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.
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关键词
Bacterial evolution,Bacterial physiology,CRISPR-Cas systems,Life Sciences,general,Microbiology,Medical Microbiology,Parasitology,Infectious Diseases,Virology
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