Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade.

Xianjuan Kou,Jie Li,Xingran Liu,Xiaoqi Yang,Jingjing Fan,Ning Chen

Biomedicine & Pharmacotherapy（2017）

引用 49|浏览9

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摘要

•d-gal can induce the atrophy of skeletal muscle associated with aging.•DHM can alleviate the atrophy of skeletal muscle through activating autophagy.•DHM can activate autophagy through SIRT1-mediated AMPK/PGC-1α signal pathway.•DHM can be a potential drug candidate for the prevention and treatment of sarcopenia.

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关键词

Ampelopsin,Skeletal muscle atrophy,d-Galactose,Autophagy,p-AMPK-PGC-1α signal pathway

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