Surplus vitamin B 12 use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease: A randomized double-blind placebo-controlled trial.

This study did not confirm the expected effect of non-conventional surplus vit B supplementation on fatigue in IBS or IBD patients. In addition, no positive effect was observed on depression or quality of life. We conclude that surplus treatment with vitamin B in IBS and IBD patients suffering from fatigue has no beneficial clinical effect.