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Influence of hydrogen sulfide on zymogen activation of homocysteine-induced matrix metalloproteinase-2 in H9C2 cardiocytes.

Zi-Shu Wang,Hong Jin,Dong-Ming Wang

Asian Pacific Journal of Tropical Medicine（2016）

Cited 9|Views6
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Abstract
Hcy can increase the production of MMP-2 secreted by H9C2 cell and improve its zymogen activation. Besides, the interaction strength is concentration-dependent; while H2S can up-regulate the activation of MMP-2 and co-promote the activation of MMP-2 with Hcy as well.
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Key words
Homocysteine,Hydrogen sulfide,Matrix metalloproteinase-2
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