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Phase 2 study evaluating intermittent and continuous linsitinib and weekly paclitaxel in patients with recurrent platinum resistant ovarian epithelial cancer.

Amit Oza,Stanley Kaye,Jan Van Tornout,Cristiana Sessa,Martin Gore,R Wendel Naumann,Hal Hirte,Nicoletta Colombo,Jihong Chen, Seema Gorla,Srinivasu Poondru,Margaret Singh,Joyce Steinberg,Geoff Yuen,Susana Banerjee

Gynecologic Oncology（2018）

Cited 23|Views26
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Abstract
•First randomized ovarian cancer trial targeting IGF1R pathway in combination with chemotherapy.•Linsitinib added to paclitaxel either as an intermittent or continuous schedule.•Addition of linsitinib did not improve outcomes in patients with ovarian cancer.
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Key words
resistant ovarian epithelial cancer,weekly paclitaxel,recurrent platinum
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