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N-Docosahexaenoylethanolamine (synaptamide): Carbon-14 radiolabeling and metabolic studies.

Shilpa Sonti,Richard I Duclos,Mansi Tolia,Samuel J Gatley

Chemistry and Physics of Lipids（2018）

Cited 12|Views13
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Abstract
•DHA-ethanolamine (synaptamide) was radiolabeled with carbon-14 in both the ethanolamine and DHA moieties.•Brain uptake of intravenous DHA-ethanolamine in mice was greater than for labeled DHA.•Both isotopomers of radiolabeled synaptamide produced radiolabeled phospholipids in mouse brain.•PF3845, a specific inhibitor of fatty acid amide hydrolase (FAAH), eliminated formation of labeled phospholipids.
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AA,DHA,DMAP,EA,EDCI,FAAH,PF3845,SYN,synaptamide
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