Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models.

Bai Liu,Monica Jones,Lin Kong, Terra Noel,Emily K Jeng,Sixiang Shi,Christopher G England,Sarah Alter,Jeffrey S Miller,Weibo Cai,Peter R Rhode,Hing C Wong

Cytokine（2018）

引用 31|浏览23

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摘要

•Comparable immune stimulation and anti-tumor efficacy post iv or sc ALT-803 in vivo.•Serum half-life and biodistribution of sc or iv ALT-803 is equivalent.•Results support sc administration of ALT-803 in clinical studies.

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关键词

IL-15N72D,IL-15RαSu

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